sarcomatoid renal cell carcinoma
Sarcomatoid renal cell carcinoma (RCC) is a tumor exhibiting marked cytologic atypia and containing enlarged pleomorphic or malignant spindle cells reminiscent of a sarcoma.
A sarcomatoid component in RCC is associated with a poor prognosis, with a median survival following diagnosis of less than 1 year reported in most studies.
A sarcomatoid component can occur in all histologic subtypes of RCC. Some reports indicate that sarcomatoid change more commonly occurs in chromophobe RCC compared with clear cell (conventional) RCC or papillary RCC.
References
Dal Cin P, Sciot R, Van Poppel H, Balzarini P, Roskams T, Van den Berghe H. Chromosome changes in sarcomatoid renal carcinomas are different from those in renal cell carcinomas. Cancer Genet Cytogenet. 2002 Apr 1;134(1):38-40. PMID: #11996794#