spindle cell rhabdomyosarcoma
Definition: The spindle cell subtype of embryonal rhabdomyosarcoma accounts for 3% of all cases. It has a fascicular, spindled, and leiomyomatous growth pattern and can demonstrate notable rhabdomyoblastic differentiation. Some neoplasms show marked collagen deposition and have a nested, storiform growth pattern. This subtype occurs predominantly in the paratesticular region and is rare in the head and neck.
Cytogenetics analysis
spindle cell rhabdomyosarcoma in adults
- t(2;7)(q36-q37;q3?) (#12550761#)
- del(14)(q24),der(16) (#12550761#)
- t(1;16)(q21;q13) (#12550761#)
See also
rhabdomyosarcomas
References
Mentzel T, Kuhnen C. Spindle cell rhabdomyosarcoma in adults: clinicopathological and immunohistochemical analysis of seven new cases. Virchows Arch. 2006 Nov;449(5):554-60. PMID: #17013628#
Nascimento AF, Fletcher CD. Spindle cell rhabdomyosarcoma in adults. Am J Surg Pathol. 2005 Aug;29(8):1106-13. PMID: #16006807#