FOXO1
MIM.136533 13q14.1 HGNC.3819
Pathology
PAX3/FOXOA1 or PAX7/FOXOA1 fusion genes in alveolar rhabdomyosarcoma
deletion in cancer
Deletion at FOXO1A was detected in 31% to 34% in 6 cell lines, 27 xenografts, and 72 clinical specimens of prostate cancer, and was significantly more frequent than deletions at surrounding loci. (#16849544#)
FOXO1A was transcriptionally down-regulated in some prostate cancers. Functionally, ectopic expression of FOXO1A inhibited, and its knockdown promoted, cell proliferation or survival. (#16849544#)
FOXO1A inhibited androgen- and androgen receptor-mediated gene regulation and cell proliferation. (#16849544#)
FOXO1A is the 13q14 tumor suppressor gene, at least in prostate cancer. (#16849544#)
As a well-established negative effector in the phosphatidylinositol 3-kinase/AKT signaling pathway, FOXO1A inactivation in cancer would impair the therapeutic effect of phosphatidylinositol 3-kinase/AKT inhibitors in cancer treatment. (#16849544#)
Constitutive phosphorylation of the FOXO1A transcription factor as a prognostic variable in gastric cancer (#17491598#)
References
Kim JH, Kim MK, Lee HE, Cho SJ, Cho YJ, Lee BL, Lee HS, Nam SY, Lee JS, Kim WH. Constitutive phosphorylation of the FOXO1A transcription factor as a prognostic variable in gastric cancer. Mod Pathol. 2007 Aug;20(8):835-42. PMID: #17491598#
Dong XY, Chen C, Sun X, Guo P, Vessella RL, Wang RX, Chung LW, Zhou W, Dong JT. FOXO1A is a candidate for the 13q14 tumor suppressor gene inhibiting androgen receptor signaling in prostate cancer. Cancer Res. 2006 Jul 15;66(14):6998-7006. PMID: #16849544#
Barr FG. Gene fusions involving PAX and FOX family members in alveolar rhabdomyosarcoma. Oncogene. 2001 Sep 10;20(40):5736-46. PMID: #11607823#
Barr, F. G.; Galili, N.; Holick, J.; Biegel, J. A.; Rovera, G.; Emanuel, B. S. Rearrangement of the PAX3 paired box gene in the paediatric solid tumor alveolar rhabdomyosarcoma. Nature Genet. 3: 113-117, 1993. PubMed ID : #8098985#