pre-eclampsia
Preeclampsia is a common, pregnancy-specific disorder characterized by reduced placental perfusion, endothelial dysfunction, elevated blood pressure, and proteinuria.
The pathogenesis of this heterogeneous disorder is incompletely understood, but it has a familial component, which suggests that one or more common alleles may act as susceptibility genes.
Susceptibility loci
2p25 (#12474145#)
9p13 (#12474145#)
Videos
Eclampsia in kidneys (by Washington Deceit)
See also
eclampsia
References
Walsh SW. Obesity: a risk factor for preeclampsia. Trends Endocrinol Metab. 2007 Dec;18(10):365-70. PMID: #18023357#
Vatish M, Randeva HS, Grammatopoulos DK. Hormonal regulation of placental nitric oxide and pathogenesis of pre-eclampsia. Trends Mol Med. 2006 May;12(5):223-33. PMID: #16616640#