Sézary syndrome
Cytogénétique
Chromosome abnormalities, mostly complex karyotypes, are seen in about 50% of patients with MF/SS, and there have only been a few instances of recurrent rearrangements.
47% of abnormal karyotype by SKY/FISH (#16382449#)
- chromosome 10
- chromosome 6 (deletion)
- chromosome 3
- chromosome 7
- chromosome 9
- chromosome 17
- chromosome 19
- chromosome 1
- chromosome 12
- chromosome 8
- chromosome 11
- chromosome 13 (deletion)
recurrent breakpoints
- 1p32-36 (#16382449#)
- 6q22-25 (#16382449#)
- 17p11.2-13 (#16382449#)
- 10q23-26 (#16382449#)
- 19p13.3(#16382449#)
pseudodicentric translocation between the short arms of chromosomes 8 - dic(17;8)(p11.2;p11.2) (#16382449#)
See also
Tumors
- Lymphomas
- cutaneous tumors
References
Batista DA, Vonderheid EC, Hawkins A, Morsberger L, Long P, Murphy KM, Griffin CA. Multicolor fluorescence in situ hybridization (SKY) in mycosis fungoides and Sezary syndrome: search for recurrent chromosome abnormalities. Genes Chromosomes Cancer. 2006 Apr;45(4):383-91. PMID: #16382449#