germ cell tumor with malignant transformation
Synopsis
germ cell component
- pure mature or immature teratoma
- teratoma mixed with other seminomatous or nonseminomatous components
- pure seminoma
- intratubular germ cell neoplasia
- yolk sac tumor
sarcomatous components (see also germ cell tumor with sarcomatous components)
- embryonal rhabdomyosarcoma (#17023832#)
- pleomorphic rhabdomyosarcoma (#18287801#)
- angiosarcoma
- leiomyosarcoma
- myxoid liposarcoma
- malignant peripheral nerve sheath tumor
- primitive neuroectodermal tumor (PNET)
- malignant "triton" tumor
- epithelioid hemangioendothelioma
- chondrosarcoma (#15590027#)
- poorly differentiated sarcoma (#15590027#)
- undifferentiated sarcoma
- anaplastic small-cell tumor
hematologic component
- leukemia
- malignant histiocytosis (#16809892#)
- histiocytic sarcoma of spleen (#16086090#)
carcinomatous component
- adenocarcinoma (#15590027#)
References
Malagon HD, Valdez AM, Moran CA, Suster S. Germ cell tumors with sarcomatous components: a clinicopathologic and immunohistochemical study of 46 cases. Am J Surg Pathol. 2007 Sep;31(9):1356-62. PMID: #17721191#
Teratoma in an adolescent with malignant transformation into embryonal rhabdomyosarcoma: case report. Sumerauer D, Vicha A, Zuntova A, Stejskalova E, Krskova L, Kabickova E, Kodet R, Eckschlager T. J Pediatr Hematol Oncol. 2006 Oct;28(10):688-92. PMID: #17023832#
True malignant histiocytosis with trisomy 9 following primary mediastinal germ cell tumor. Suenaga M, Matsushita K, Kawamata N, Kukita T, Hamakawa Y, Gejima K, Onodera R, Sato T, Yamaguchi A, Inoue H, Arimura K, Arima N, Yoshida H, Tei C. Acta Haematol. 2006;116(1):62-6. PMID: #16809892#
Mediastinal germ cell tumor associated with histiocytic sarcoma of spleen: case report of an unusual association. Song SY, Ko YH, Ahn G. Int J Surg Pathol. 2005 Jul;13(3):299-303. PMID: #16086090#
Anterior mediastinal nonseminomatous germ cell tumor with malignant transformation: a case report. Michel M, Pratt JW. Curr Surg. 2004 Nov-Dec;61(6):576-9. PMID: #15590027# (yolk sac tumor, teratoma, chondrosarcoma, adenocarcinoma, and poorly differentiated sarcoma)
Chemotherapy for teratoma with malignant transformation. Donadio AC, Motzer RJ, Bajorin DF, Kantoff PW, Sheinfeld J, Houldsworth J, Chaganti RS, Bosl GJ. J Clin Oncol. 2003 Dec 1;21(23):4285-91. PMID: #14645417#