inflammatory liposarcoma
Definition: Inflammatory liposarcoma is a variant of well-differentiated liposarcoma/atypical lipomatous tumor that consists of a mixture of lymphocytes, histiocytes, scattered atypical stromal cells, mature adipocytes, and rarely lipoblasts.
Well-differentiated liposarcoma/atypical lipomatous tumor and dedifferentiated liposarcoma have characteristic molecular markers in the form of giant marker and ring chromosomes consisting of amplicons of 12q13-15, which includes MDM2.
Differential diagnosis
When the inflammatory infiltrate predominates, the morphological features overlap with various fibroinflammatory disorders including sclerosing mesenteritis and retroperitoneal fibrosis, making the diagnosis difficult. Lack of MDM2 immunoexpression would rule out the possibility of inflammatory well-differentiated liposarcoma (#18836421#)
sclerosing mesenteritis
retroperitoneal fibrosis
References
Management of spermatic cord liposarcoma in renal transplant recipients: case report. Manzia TM, Gravante G, Toti L, Iaria G, Anselmo A, Fratoni S, Angelico R, Sforza D, Manuelli M, Tisone G. Transplant Proc. 2010 May;42(4):1355-7. PMID: #20534300#
Synchronous presentation of uterine leiomyosarcoma and retroperitoneal liposarcoma: analysis by comparative genomic hybridization and review of the literature. Chen HK, Huang HY, Li CF, Ko SF, Changchien CC, Chen WJ, Huang CC. Int J Gynecol Pathol. 2009 Nov;28(6):535-40. PMID: #19851200#
Weaver J, Goldblum JR, Turner S, Tubbs RR, Wang WL, Lazar AJ, Rubin BP. Detection of MDM2 gene amplification or protein expression distinguishes sclerosing mesenteritis and retroperitoneal fibrosis from inflammatory well-differentiated liposarcoma. Mod Pathol. 2008 Oct 3. PMID: #18836421#
Sclerosing poorly differentiated liposarcoma: clinicopathological, immunohistochemical and molecular analysis of a distinct morphological subtype of lipomatous tumour of soft tissue. Suster S, Morrison C. Histopathology. 2008 Feb;52(3):283-93. PMID: #18269578#
Well-differentiated inflammatory liposarcoma: an uncommon and easily overlooked variant of a common sarcoma. Kraus MD, Guillou L, Fletcher CD. Am J Surg Pathol. 1997 May;21(5):518-27. PMID: #9158675#