adult yolk sac tumor
Characteristics
presents along with other germ cell tumor components.
Isochrome 12p positive
Intratubular neoplasia is present.
Usually aneuploid p53 gene mutations.
Lymphatic route is primarily spread for metastases.
Often presents as higher stage disease
Nota bene: prepubertal yolk sac tumor
Isochrome 12p is not seen
Euploid or tetraploid
Recurrent nonrandom chromosomal abnormalities: 1p deletion, 3p duplication, 6q deletion
p53 gene mutations absent.
Equal incidence of lymphatic and hematogenous spread for metastases.
Presents as stage I disease (85%)
See also
yolk sac tumor