differentiated adamantinoma
Differential diagnosis
osteofibrous dysplasia (ossifying fibroma)
Cytogenetics
trisomy 7
trisomy 8
trisomy 12
trisomy 19
tumoral trisomy 21
Nosology
It has been surmised that osteofibrous dysplasia (OFD) (ossifying fibroma) and adamantinoma are on a continuum with osteofibrous dysplasia-like adamantinoma representing an intermediate step between the two lesions.
Findings indicate that osteofibrous dysplasia, differentiated adamantinoma, and adamantinoma, should be regarded as related conditions. However, only rarely does a case of osteofibrous dysplasia or differentiated adamantinoma eventually act in a malignant fashion.
Genetic studies have also pointed to a relationship between OFD and adamantinoma in that the tumors have been found to share recurrent trisomies (chromosomes 7, 8, 12, and 21).
See also
adamantinoma
- dedifferentiated adamantinoma
fibrous tumors of bones