dedifferentiated liposarcoma
Dedifferentiated liposarcoma (DLPS) is one of the most frequent sarcomas of the retroperitoneum and represents most undifferentiated sarcomas of the internal trunk.
In about 5% cases, the dedifferentiated component is an heterologous sarcoma such as leiomyosarcoma or rhabdomyosarcoma.
Variants
dedifferentiated liposarcoma with rhabdomyoblastic differentiation (#16012847#)
dedifferentiated liposarcoma with "homologous" lipoblastic differentiation (pleomorphic liposarcoma-like) (#20588177#)
Cytogenetics
Cytogenetic anomalies similar to those seen in atypical lipomatous tumor/well-differentiated liposarcoma (ALT/WDLS)
Differential diagnosis
Dedifferentiated liposarcoma (DDL), occurring in up to 10% of well differentiated liposarcoma cases, has similar histologic features to that of undifferentiated high-grade pleomorphic sarcoma (UHGPS); the former develops in a background of atypical lipomatous tumors/well differentiated liposarcoma, whereas the latter shows no specific line of differentiation. The retroperitoneum and thigh represent the most common anatomic locations for both the sarcomas. (#19574885#)
References
Dedifferentiated liposarcoma with "homologous" lipoblastic (pleomorphic liposarcoma-like) differentiation: clinicopathologic and molecular analysis of a series suggesting revised diagnostic criteria. Mariño-Enríquez A, Fletcher CD, Dal Cin P, Hornick JL. Am J Surg Pathol. 2010 Aug;34(8):1122-31. PMID: #20588177#
Overlapping Features Between Dedifferentiated Liposarcoma and Undifferentiated High-Grade Pleomorphic Sarcoma. Chung L, Lau SK, Jiang Z, Loera S, Bedel V, Ji J, Weiss LM, Chu PG. Am J Surg Pathol. 2009 Jul 1. PMID: #19574885#
Binh MB, Guillou L, Hostein I, Chateau MC, Collin F, Aurias A, Binh BN, Stoeckle E, Coindre JM. Dedifferentiated Liposarcomas With Divergent Myosarcomatous Differentiation Developed in the Internal Trunk: A Study of 27 Cases and Comparison to Conventional Dedifferentiated Liposarcomas and Leiomyosarcomas. Am J Surg Pathol. 2007 Oct;31(10):1557-1566. PMID: #17895758#
Shimada S, Ishizawa T, Ishizawa K, Kamada K, Hirose T. Dedifferentiated liposarcoma with rhabdomyoblastic differentiation. Virchows Arch. 2005 Nov;447(5):835-41. PMID: #16012847#
Coindre JM, Hostein I, Maire G, Derre J, Guillou L, Leroux A, Ghnassia JP, Collin F, Pedeutour F, Aurias A. Inflammatory malignant fibrous histiocytomas and dedifferentiated liposarcomas: histological review, genomic profile, and MDM2 and CDK4 status favour a single entity. J Pathol. 2004 Jul;203(3):822-30. PMID: #15221942#
Coindre JM, Mariani O, Chibon F, Mairal A, De Saint Aubain Somerhausen N, Favre-Guillevin E, Bui NB, Stoeckle E, Hostein I, Aurias A. Most malignant fibrous histiocytomas developed in the retroperitoneum are dedifferentiated liposarcomas: a review of 25 cases initially diagnosed as malignant fibrous histiocytoma. Mod Pathol. 2003 Mar;16(3):256-62. PMID: #12640106#