RAP1GA1
MIM.600278 1p36.1-p35
The p21 protein RAP1 is of particular interest since it has been shown to be an antagonist of RAS and is capable of suppressing cellular transformation. It has been suggested that RAP1 binds competitively to RASA, thus interfering with its RAS effector functions.
References
Kometani K, Ishida D, Hattori M, Minato N. Rap1 and SPA-1 in hematologic malignancy. Trends Mol Med. 2004 Aug;10(8):401-8. PMID: #15310461#