nuclear pore complexes
The nuclear import of proteins through nuclear pore complexes (NPCs) illustrates how a complex biological function can be generated by a spatially and temporally organized cycle of interactions between cargoes, carriers and the Ran GTPase.
See also
nuclear pore complexes assembly
nucleocytoplasmic transport
NUPs (nucleoporins)
nuclear envelope
References
Stewart M. Molecular mechanism of the nuclear protein import cycle. Nat Rev Mol Cell Biol. 2007 Mar;8(3):195-208. PMID: #17287812#
Sazer S. Nuclear envelope: nuclear pore complexity. Curr Biol. 2005 Jan 11;15(1):R23-6. PMID: #15649347#
Mosammaparast N, Pemberton LF. Karyopherins: from nuclear-transport mediators to nuclear-function regulators. Trends Cell Biol. 2004 Oct;14(10):547-56. PMID: #15450977#
Rabut G, Lenart P, Ellenberg J. Dynamics of nuclear pore complex organization through the cell cycle. Curr Opin Cell Biol. 2004 Jun;16(3):314-21. PMID: #15145357#
Cronshaw JM, Matunis MJ. The nuclear pore complex: disease associations and functional correlations. Trends Endocrinol Metab. 2004 Jan-Feb;15(1):34-9. PMID: #14693424#
Rout MP, Aitchison JD, Magnasco MO, Chait BT. Virtual gating and nuclear transport : the hole picture. Trends Cell Biol. 2003 Dec ;13(12):622-8. PMID : #14624840#