infantile germ cell tumors
Human germ cell tumors (GCTs) of neonates and infants comprise a heterogeneous group of neoplasms, including teratomas and yolk sac tumors with distinct clinical and epidemiologic features.
Array-based comparative genomic hybridization (array CGH) (#15880464#)
Under 5 years
- most teratomas displayed normal profiles, except for some minor recurrent aberrations.
- yolk sac tumors
- losses of 1p35-pter
- gains of 3p21-pter
- gains of 20q13
patients older than 5 years
- gains of 12p
- gains of whole chromosomes 7 and 8
GCTs of varied histology, independent of age
- gains of the 1q32-qter region
- losses of the 6q24-qter and 18q21-qter regions
See also
ccongenital germ cell tumors (neonatal germ cell tumors) (NGCTs)
References
Veltman IM, Schepens MT, Looijenga LH, Strong LC, van Kessel AG. Germ cell tumours in neonates and infants: a distinct subgroup? APMIS. 2003 Jan;111(1):152-60; discussion 160. PMID: #12752256#