desmoplastic nested spindle cell tumor of liver

Synopsis

 nested spindled and epithelioid cells with extensive desmoplasia
 well circumscribed, lobular white masses, ranging from 2.8 to 15 cm in diameter
 cohesive nests of plump, bland spindle cells arranged in short fascicles with an accompanying desmoplastic stroma
 epithelioid areas ranging from palisading epithelioid cells at the periphery of some nests to pseudoglandular and polygonal cells with intercellular bridges
 low mitotic activity
 calcification
 ossification
 non-neoplastic bile ducts and hepatic elements were seen both within and surrounding the tumor cell nests

Immunochemistry

 vimentin+
 pan-cytokeratin+
 CD57+
 WT1+ (nuclear staining)
 neuroendocrine markers negative

Ultrastructure

 focally well-developed cell junctions
 basal lamina
 few cytoplasmic organelles

References

 Hill DA, Swanson PE, Anderson K, Covinsky MH, Finn LS, Ruchelli ED, Nascimento AG, Langer JC, Minkes RK, McAlister W, Dehner LP. Desmoplastic nested spindle cell tumor of liver: report of four cases of a proposed new entity. Am J Surg Pathol. 2005 Jan;29(1):1-9. PMID: 15613851