TLN1
MIM.186745 9p
Cell-matrix adhesions involve transmembrane glycoproteins such as cell adhesion molecules (CAMs) and integrins (ITGs), which are thought to function via interactions of their cytoplasmic domains with proteins associated with the cytoskeleton, as vinculin (VCL) or talins (TLNs: TLN1 and TLN2).
TLN1 serves a function of linking vinculin (VCL) (MIM.193065) to the integrins (ITGs), and, thus, the cytoskeleton to extracellular matrix (ECM) receptors.
TLN1 has a mass of 270 kD and shares 23% N-terminal identity with ezrin (VIL2) (MIM.123900), which has similar functions.
Members
| TLN1 | TLN2 |
See also
cell-matrix adhesion
cell adhesion molecules (CAMs)
integrins (ITGs)