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splenic littoral cell angioma
Thursday 20 April 2006
Synopsis
minute foci to large nodules almost completely replacing the splenic tissue
anastomosing vascular channels resembling splenic sinus
irregular lumina
papillary projections
cyst-like spaces
lined by tall endothelial cells that slough off into the vascular lumina and show hemophagocytosis
atypical cells absent
mitotic activity very low
Immunochemistry
neoplastic cells express both endothelial (FVIII-AG, BMA 120) and histiocytic (KP1, lysozyme) antigens
+/- S-100 +
References
Metastasizing splenic littoral cell hemangioendothelioma. Fernandez S, Cook GW, Arber DA. Am J Surg Pathol. 2006 Aug;30(8):1036-40. PMID: 16861977
Falk S, Stutte HJ, Frizzera G. Littoral cell angioma. A novel splenic vascular lesion demonstrating histiocytic differentiation. Am J Surg Pathol. 1991 Nov;15(11):1023-33. PMID: 1928554