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ASC-H
Sunday 22 September 2019
Definition : atypical squamous cells with high-grade lesions that cannot be excluded (ASC-H).
WHO : https://screening.iarc.fr/atlasglossdef.php?key=ASC-H&img;
The Bethesda System 2001: ASC-H: atypical squamous cells, cannot exclude high grade lesion. They represent less than 10% of ASC.
New term in ASC, to individualise cytologic changes of squamous cells that are suggestive of HSIL but lack criteria required for a definitive interpretation.
These cases are associated with a higher risk of intraepithelial lesions, more often with CIN2 and CIN3 than in ASC-US smears.
Types
numerous naked nuclei in groups from reserve cell hyperplasia (RCH), with nuclear size variations
isolated naked nuclei from reserve cell hyperplasia (RCH), with nuclear size variations
isolated naked nuclei, hypo or hyperchromatic, from reserve cell hyperplasia (RCH), with nuclear size variations
Large groups of immature atypical cells some with nucleoli (atypical immature metaplasia (arrow) or atypical repair?), sometimes more columnar-shaped
cohesive cluster of atypical cells (immature metaplasia) with nuclear enlargement, hyperchromasia and anisokaryosis
group of immature, atypical metaplastic cells with markedly enlarged nuclei
See also
ASC-US
LSIL
HGIL